The cancer stem cell model also applies to some cancers of the nervous system, such as medulloblastoma, gliomas, and ependymomas 11,12,56. Mesenchymal stem cells in cancer therapy atashzar mr j can. Several features of the mammary stem cells predispose them to play a critical role in breast cancer initiation, progression and metastasis. This book is the definitive guide to reverting cancer cells into normal cells. Second part of the book covers the application of stem cells in treatment of various types of. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are. Stem cells and cancer stem cells, volume 5 therapeutic. Despite preventive mechanisms adult stem cells may accumulate mutations over the years. The volume covers extensive topics such as identification and isolation of cancer stem cells, animal models of cancer stem cells. Over the last thirty years, the foremost inspiration for research on metastasis, cancer recurrence, and increased resistance to chemo and radiotherapy has been the notion of cancer stem cells. It is emphasized that a cancer stem cell is a tumor initiating cell. Stem cells, cancer, and epigenetics stembook ncbi bookshelf. It is emphasized that a unique feature of cancer stem cells is that, although conventional. Cancer stem cells theories and practice intechopen.
List of books and articles about stem cell research. The volume covers extensive topics such as identification and isolation of cancer stem cells, animal models of cancer stem cells, methylation profiling, the contribution of the niche in the regulation of cancer stem cells, immunologic targeting, and the use of normal stem cells. Gastric carcinoma is a multifactorial disease, involving a chronic helicobacter pylori infection as the main cause as well as the epsteinbarr virus to a small extent, diet low vitamins, nitrosamines, chemicals, etc. Cancer stem cells theories and practice is firmly grounded in the latest results on cancer stem cells cscs from worldclass cancer. Cancer stem cells theories and practice is firmly grounded in the latest results on cancer stem cells cscs from worldclass cancer research laboratories, but its twentytwo chapters also tease apart cancer s vulnerabilities and identify opportunities for early detection, targeted therapy, and reducing remission and resistance. Such a presentation facilitates a better understanding of and draws attention to stem cell and cancer biology two fields that enhance, move, and evolve into each other continuously. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes. First part of the book covers stem cells in organogenesis and regeneration of tissueorgans in model organism to humans using embryonic stem cell, cord blood stem cells, germline stem cells, and adult stem cells.
As the first book in its field, cancer stem cells is an invaluable repository of information for cancer biologists, stem cell researchers, and clinicians. Stem cell transplants are procedures that restore bloodforming stem cells in cancer patients who have had theirs destroyed by very high doses of chemotherapy or radiation therapy. Cancer stem cells lucie laplane harvard university press. Henrietta lacks immortal cells science smithsonian. The fundamental abnormality resulting in the development of cancer is the continual unregulated proliferation of cancer cells. The stem cell theory of cancer ludwig center stanford. This detailed volume gathers a comprehensive collection of methods, protocols, and procedures used for the identification, characterization, and selection of cancer stem cells.
Cancer stem cells in breast cancer, brain tumors, certain forms of leukemia, and gastric tumor. Stem cell transplants in cancer treatment national cancer. Jan 22, 2010 in her new book, the immortal life of henrietta lacks, journalist rebecca skloot tracks down the story of the source of the amazing hela cells, henrietta lacks, and documents the cell lines. Cscs are a subset of tumor cells, found at the center of a tumor mass, possessing the ability to selfrenew and differentiate, both characteristics thought to be related to tumor maintenance and carcinogenesis. This book is a wellset book, which has been prepared for understanding the role of mesenchymal stem cells msc at the treatment of cancer. Each chapter begins with a brief historical note and concept summary.
Cancer biologists believe that cancer stem cells, like other adult stem cells, can both divide into new stem cells and differentiate into more specialized cells. They exhibit distinctive selfrenewal, proliferation, and differentiation capabilities that are believed to play a critical role in cancer initiation, maintenance, progression, drug resistance, and cancer recurrence or. Nci dictionary of cancer terms national cancer institute. Rather, cancer stem cells theories and practice boldly goes where the cutting edge of research theory meets the concrete challenges of clinical practice. Through the revolutionary concept of cancer stem cells, cancer research has been reinvigorated to study the role of these unique cells in cancer propagation and as targets of innovative therapies. Cscs are a subset of tumor cells, found at the center of a. Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organspecific identifications, and their characteristic mechanisms. Stem cells and cancer stem cells, volume 2 springerlink. Types of stem cell and bone marrow transplants what cancer patients, their families, and caregivers need to know about the coronavirus. As in volume 1 of this series, this volume presents information on stem cells and cancer stem cells. Such an approach is significant since it was galen who promoted the use of logic, and in fact the full trivium, as an integral part of the practice of medicine. In her new book, the immortal life of henrietta lacks, journalist rebecca skloot tracks down the story of the source of the amazing hela cells, henrietta lacks, and documents the cell lines.
Rather than responding appropriately to the signals that control normal cell behavior, cancer cells grow and divide in an uncontrolled manner, invading normal tissues and organs and eventually spreading throughout the body. Jan 31, 2014 cancer stem cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how theyre generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Blood cancers like leukaemia occur when mutations in stem cells cause them to produce too many blood cells. A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at. Therapeutic applications in disease and tissueorgan injury.
Lucie laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that. This book represents an updated summary of the state of the art of the characterization of cancer stem cell cancer initiating cell csccic properties. There are 3 types of stem cell transplants, based on who donates the cells. It is a broad look at the exciting stem cell field, warts and all. Looking for a stem cell book that is clear and tells the real story of stem cells. Tumorinitiating cells, cancer metastasis and therapeutic.
Cancer stem cell is a progressive concept moving forward to interpret the hardtocure nature of cancer and the relevant behavior in response to clinical therapies. Learn about the types of transplants and side effects that may occur. Stem cells, cancer, and epigenetics ncbi bookshelf. Research has shown that cancer cells are not all the same. Oct 31, 2009 this is a timely juxtaposition since there is also a growing body of data suggesting that cancer steminitiating cells, especially when they may dominate in the most aggressive forms of human tumors, have a gene expression signature reminiscent of es cells.
Cells free fulltext role of mirnaregulated cancer stem. A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Essentials of cancer stem cells and conceptual modeling. Stem cells is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. Pancreatic cancer stem cells and therapeutic approaches. Within a malignant tumor or among the circulating cancerous cells of a leukemia, there can be a variety of types of cells. This book summarizes the latest findings about the role of cancer stem cells cscs in cancer biology and how this knowledge could be used for novel. Lucie laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Blood stem cells are found in the peripheral blood and the bone marrow. Chapters include emerging provocative evidence that a cancer stem cell, although still necessarily defined operationally, actually refers to a molecular state that may be unstable or altered reversibly.
Cancer stem cells cscs or cancer initiating cells are a subpopulation of cells that has the driving force of carcinogenesis. The nature and clinical relevance of cancer stem cells are timely topics covered with an appropriately broad and insightful brush in this comprehensive book devoted entirely to this subject. This is a timely juxtaposition since there is also a growing body of data suggesting that cancer stem initiating cells, especially when they may dominate in the most aggressive forms of human tumors, have a gene expression signature reminiscent of es cells. Methods and protocols, preeminent researchers have compiled cancer stem cell research techniques and protocols to promote healthy competition, discourse, and collaboration in this vital field.
Recent biomedical discoveries have revolutionized the concept and understanding of carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic, epigenetic, biochemical, and histological changes, with special reference to micrornas mirnas and cancer stem cells cscs. Role of neural cancer stem cells in brain tumors, including their role in brain tumor therapy and the role of cd3 stem cell antigen in glioma patients, is emphasized. Mesenchymal stem cells in cancer therapy sheds light on current stem cell based targeted therapies for cancer, by focusing on the application of mesenchymal stem cells msc in various cancers with emphasis on a number of aspects that are critical to the success of future stem cell based therapies for cancer. Stem cells and cancer stem cells, volume 1 hayat, m. It also mentions a dozen substances that are known in test tube to revert cancer cells into normal cells, thus proving it can be done. Cancer stem cells wiley online books wiley online library. So, rafii says, if you dont get rid of those few cancer stem cellseven if you kill the other 95 percent of the tumorthen the cancer is going to continue to grow.
It contains a lot of references to research studies. The development and causes of cancer the cell ncbi. The twentyeight chapters assembled in cancer stem cells the cutting edge summarize the work of cancer researchers and oncologists at leading universities and hospitals around the world on every aspect. Role of neural cancer stem cells in brain tumors, including their role in brain tumor therapy and the role of cd3 stem cell antigen in glioma. Cancer stem cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how theyre generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Methodologies of regenerative medicine and tissue engineering are major components of this volume. The book also explores innovative therapeutic strategies in. Despite the remaining debates regarding the existence of cancer stem cells, the cancer stem cell model provides a potential approach for advanced innovative therapies targeting the roots of cancer, which has enhanced. Mechanistic studies of cells, cell organelles, subcellular molecular pathways and metabolism.
The cancer stem cell hypothesis has challenged the foundational notions of cancer, and the therapeutic implications have been profound. August 1, 1920 october 4, 1951 was an africanamerican woman whose cancer cells are the source of the hela cell line, the first immortalized human cell line and one of the most important cell lines in medical research. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. Unknown whether the tissue stem cell degenerates, or if a more differentiated cell reacquires stem cell phenotype. It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. Cancer stem cell may the origination of children acute lymphoblastic leukemia the development of the tumour is always believed to be the result of a succession of epigeneticgenetic alterations and selection steps which leading to the emergence of cells accumulating survival and proliferation advantages. In contrast to sp, a novel approach based on the ability of stem cells to retain pkh26, 22 a lipophilic fluorescent dye which stains quiescent cells, was used for the isolation of human normal mammary stem cells and to further characterize breast cscs.
From the essentials to application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. Aging, cancer and age related disorders advances in experimental medicine and biology by karl l. An immortalized cell line reproduces indefinitely under specific conditions, and the hela cell line continues to be a source of. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem. The application of human pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells in cancer therapy and tissueorgan regeneration is detailed. These include surface marker expression, side population, spheres formation, aldh activity, and numerous others. The volume covers extensive topics such as identification and isolation of cancer stem cells, animal models of cancer stem cells, methylation profiling, the contribution of the niche in the regulation of cancer stem cells, immunologic targeting, and the use of normal stem cells as a treatment, among other subjects. Cancer stem cell resistance to targeted therapy cristina. Stem cell book the niche knoepfler lab stem cell blog. Mesenchymal stem cells in cancer therapy sciencedirect. The recent book by laplane on cancer stem cells is a brilliantly wellcrafted introduction to the field from is a philosophical perspective. Stem cells and cancer stem cells,volume 3 stem cells and. Stem cell transplants in cancer treatment national. Highly recommended books on alternative cancer treatments.
Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. In each of these cases, a minority subpopulation of cancer cells with phenotypic and functional features of neural stem cells appears uniquely capable of proliferating in culture and forming tumors in vivo. Despite the remaining debates regarding the existence of cancer stem cells, the cancer. Cancer stem cells cscs are a small subpopulation of cells within tumors with capabilities of selfrenewal, differentiation, and tumorigenicity when transplanted into an animal host. Cancer stem cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how theyre generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back at least epigenetically into nontumor forming cells. Role of cancer stem cells in cancer biology and therapy crc. It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of selfrenewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. The role of stem cells in breast cancer intechopen. Cancer stem cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Cancer stem cells cscs have dominated the cancer and stem cell research sector in recent years. Cancer stem cell is a progressive concept moving forward to interpret the. Cancer stem cells cscs are cancer cells found within tumors or hematological cancers that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample.
It will serve as a springboard to understanding the mechanisms of cscs and their potential for developing new, more effective therapeutics. Final twist to tale of henrietta lacks, the woman whose. The discovery could pave the way for new, targeted medical treatments that block this process. As revealed in the bestselling 2011 book the immortal life of henrietta lacks, this is a tale of a poor black tobacco farmer who never consented to having her tissues taken but whose cancer cells. The twentyeight chapters assembled in cancer stem cells the cutting edge summarize the work of. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer. The journal publishes key, wellcontrolled advances in stem cell clinical trials and mechanismbased manuscripts with. Mar 11, 2008 cancer stem cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Stem cells and cancer stem cells, volume 1 springerlink. New finding reopens the book on colon cancer stem cells. The stem cell theory of cancer proposes that among all cancerous cells, a few act as stem cells that reproduce. Cambridge core oncology cancer stem cells edited by william l.
Despite the considerable progress in cancer therapy, novel therapeutic approaches for covering pitfalls of current treatments are need. Hans clevers admires an analysis of stem cell science that sharpens up some of the fuzziness in the field. Mar 30, 20 as revealed in the bestselling 2011 book the immortal life of henrietta lacks, this is a tale of a poor black tobacco farmer who never consented to having her tissues taken but whose cancer cells. Final twist to tale of henrietta lacks, the woman whose cells. Treatment with stem cells in humans is experimental and can have unexpected and damaging sideeffects. Cancer stem cells perspectives and how to target them.
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